{"id":2338,"date":"2018-12-11T13:35:32","date_gmt":"2018-12-11T12:35:32","guid":{"rendered":"https:\/\/blog.ki.se\/rektor\/?p=2338"},"modified":"2018-12-11T14:43:26","modified_gmt":"2018-12-11T13:43:26","slug":"nobel-week-we-live-in-the-most-dynamic-of-times","status":"publish","type":"post","link":"https:\/\/blog.ki.se\/rektor\/2018\/12\/11\/nobel-week-we-live-in-the-most-dynamic-of-times\/","title":{"rendered":"Nobel week: We live in the most dynamic of times"},"content":{"rendered":"<p>The Nobel Prize and the Nobel week are about progress \u2013 how excellent research and excellent achievements bring us forward. It is when we see all the Nobel prizes in context that we get a glimpse of Alfred Nobel\u2019s insight and hopes when he crafted his will just before the 19<sup>th<\/sup> century ebbed out.<\/p>\n<p>This year\u2019s Nobel Prizes attest to the power of basic research, to the power of interdisciplinarity, and to the power of compassion, empathy and concern for the individual human being. I\u2019ve been a keen observer of the Nobel Prizes for decades and rarely have I seen such a timely and complementary set of awards.<\/p>\n<p>I had the pleasure of providing the opening statement and welcoming remarks for the Nobel lectures in Physiology or Medicine last Friday, by James P. Allison and Tasuku Honjo. The lectures were given in our beautiful Aula Medica which was filled to capacity.<\/p>\n<h4><strong>A chronic disease<\/strong><\/h4>\n<p>If there is one remark that lingers in my mind after these lectures, it is this: <em>cancer is about to become a chronic disease.<\/em> I am not sure if these were Honjo\u2019s exact words, but this was his message. With the new treatments \u2013 including those honored by the Nobel Prize this year \u2013 a growing proportion of cancer patients will experience remissions that last for a lifetime \u2013 essentially converting an acute and often deadly malady into a chronic one.<\/p>\n<p>For decades we have been used to seeing improvements in cancer treatment as rather modest right shifts of the survival curves. Now we are exposed to curves that level off a few years after disease onset, indicative of long term survival for those that respond. So far, the new treatments have proven efficient only for a limited number of cancer diseases. But progress is being made and hope is instilled for a better treatment of some of the most serious cancers that we as humans can fall victim to.<\/p>\n<h4><strong>Fundamental research<\/strong><\/h4>\n<p>Being a basic scientist myself, I was intrigued by the emphasis that Allison and Honjo placed on fundamental research and the long term merits thereof. Certainly, the identification of the \u201cbrakes\u201d that normally prevent immune cells from effectively attacking tumors is a result of curiosity driven research of the highest quality. Through the lectures we saw how insight gained from basic research gradually translated into disruptive changes in cancer treatment. Translation takes time. The story behind this year\u2019s Nobel Prize to Allison and Honjo \u201cfor their discovery of cancer therapy by inhibition of negative immune regulation\u201d highlights the importance of basic research, the need for long term funding, and the value of stamina and courage on the part of those engaged in medical science.<\/p>\n<p>\u201cA creative use of nature\u201d was a concept that came up time and time again during the mingling after the lectures. An apt concept indeed. Instead of killing the cancer cells directly, by radiation or drugs, Allison and Honjo let nature do the job. In his speech at the Nobel banquet yesterday, Honjo paid tribute to the immune system and to acquired immunity specifically. Well deserved: it is the evolution of this system that now allows \u201cdisinhibited\u201d T-cells to attack cells that are malignantly transformed.<\/p>\n<h4><strong>Recurrent theme<\/strong><\/h4>\n<p>Harnessing the power of nature and evolution for the benefit of health can be seen as recurrent theme for this year\u2019s Nobel Prizes. The chemistry prize awarded scientists that made use of enzymes and antibodies for a greener chemistry and more sophisticated diagnosis and treatment. The physics prize honored researchers that utilized the power of light in a way that has hugely benefited surgery and medicine at large. Even the economy prize can be seen in the context of health: we know that climate change threatens the health of our planet and through this the health of the individual human being.<\/p>\n<p>Finally: this year\u2019s peace prize has everything to do with health. Denis Mukwege and Nadia Murad have made tremendous efforts to protect victims of wartime sexual violence. Their achievements and personal histories make us see health in the broadest of contexts. Their work instills hope.<\/p>\n<p>We live in the most dynamic of times. Collectively the 2018 Nobel Prizes tell us how progress is made, through science, through creative use of nature, and through compassion and empathy for our fellow human beings.<\/p>\n<p>More information about the Nobel Prize in physiology or medicine can be found at <a href=\"https:\/\/ki.se\/en\/about\/the-nobel-prize-in-physiology-or-medicine\" target=\"_blank\" rel=\"noopener\">KI&#8217;s web site<\/a>. Video of the Nobels lectures are availiable <a href=\"https:\/\/www.youtube.com\/watch?v=slHiM-PBTJ8\" target=\"_blank\" rel=\"noopener\">througt this site<\/a>. There is also an article on the Nobel lectures in Aula Medica at <a href=\"https:\/\/ki.se\/nyheter\/botade-cancerpatienter-i-fokus-nar-nobelpristagare-forelaste-pa-ki\" target=\"_blank\" rel=\"noopener\">KI&#8217;s website<\/a> (in Swedish, an English version will be published soon).<\/p>\n<p>&nbsp;<\/p>\n<p><img decoding=\"async\" class=\"wp-image-2353 aligncenter\" src=\"https:\/\/blog.ki.se\/rektor\/wp-content\/uploads\/sites\/42\/2018\/12\/Nobel-lectures.jpg\" alt=\"\" width=\"460\" height=\"690\" srcset=\"https:\/\/blog.ki.se\/rektor\/wp-content\/uploads\/sites\/42\/2018\/12\/Nobel-lectures.jpg 1080w, https:\/\/blog.ki.se\/rektor\/wp-content\/uploads\/sites\/42\/2018\/12\/Nobel-lectures-200x300.jpg 200w, https:\/\/blog.ki.se\/rektor\/wp-content\/uploads\/sites\/42\/2018\/12\/Nobel-lectures-768x1152.jpg 768w, https:\/\/blog.ki.se\/rektor\/wp-content\/uploads\/sites\/42\/2018\/12\/Nobel-lectures-683x1024.jpg 683w, https:\/\/blog.ki.se\/rektor\/wp-content\/uploads\/sites\/42\/2018\/12\/Nobel-lectures-67x100.jpg 67w\" sizes=\"(max-width: 460px) 100vw, 460px\" \/><\/p>\n<p style=\"text-align: center\"><em>Tasuku Honjo<\/em><\/p>\n<p><img decoding=\"async\" class=\"wp-image-2351 aligncenter\" src=\"https:\/\/blog.ki.se\/rektor\/wp-content\/uploads\/sites\/42\/2018\/12\/Nobel-lectures-Allison.jpg\" alt=\"\" width=\"449\" height=\"675\" srcset=\"https:\/\/blog.ki.se\/rektor\/wp-content\/uploads\/sites\/42\/2018\/12\/Nobel-lectures-Allison.jpg 1080w, https:\/\/blog.ki.se\/rektor\/wp-content\/uploads\/sites\/42\/2018\/12\/Nobel-lectures-Allison-200x300.jpg 200w, https:\/\/blog.ki.se\/rektor\/wp-content\/uploads\/sites\/42\/2018\/12\/Nobel-lectures-Allison-768x1152.jpg 768w, https:\/\/blog.ki.se\/rektor\/wp-content\/uploads\/sites\/42\/2018\/12\/Nobel-lectures-Allison-67x100.jpg 67w\" sizes=\"(max-width: 449px) 100vw, 449px\" \/><\/p>\n<p style=\"text-align: center\"><em>James P. Allison<\/em><\/p>\n<p><img decoding=\"async\" class=\"alignnone wp-image-2352 aligncenter\" src=\"https:\/\/blog.ki.se\/rektor\/wp-content\/uploads\/sites\/42\/2018\/12\/Nobel-lectures-Olep.jpg\" alt=\"\" width=\"584\" height=\"389\" srcset=\"https:\/\/blog.ki.se\/rektor\/wp-content\/uploads\/sites\/42\/2018\/12\/Nobel-lectures-Olep.jpg 1620w, https:\/\/blog.ki.se\/rektor\/wp-content\/uploads\/sites\/42\/2018\/12\/Nobel-lectures-Olep-300x200.jpg 300w, https:\/\/blog.ki.se\/rektor\/wp-content\/uploads\/sites\/42\/2018\/12\/Nobel-lectures-Olep-768x512.jpg 768w, https:\/\/blog.ki.se\/rektor\/wp-content\/uploads\/sites\/42\/2018\/12\/Nobel-lectures-Olep-1024x683.jpg 1024w, https:\/\/blog.ki.se\/rektor\/wp-content\/uploads\/sites\/42\/2018\/12\/Nobel-lectures-Olep-150x100.jpg 150w\" sizes=\"(max-width: 584px) 100vw, 584px\" \/><\/p>\n<p style=\"text-align: center\"><em>All photos: Erik Cronberg<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"<p>The Nobel Prize and the Nobel week are about progress \u2013 how excellent research and excellent achievements bring us forward. It is when we see all the Nobel prizes in [&hellip;]<\/p>\n","protected":false},"author":100,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[289],"tags":[249,55],"class_list":["post-2338","post","type-post","status-publish","format-standard","hentry","category-nobelpris","tag-cancer","tag-nobel-prize"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Nobel week: We live in the most dynamic of times - Ole Petter Ottersen, president Karolinska Institutet 2017-2023<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/blog.ki.se\/rektor\/2018\/12\/11\/nobel-week-we-live-in-the-most-dynamic-of-times\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Nobel week: We live in the most dynamic of times - Ole Petter Ottersen, president Karolinska Institutet 2017-2023\" \/>\n<meta property=\"og:description\" content=\"The Nobel Prize and the Nobel week are about progress \u2013 how excellent research and excellent achievements bring us forward. 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